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Resolving Neurodevelopmental and Vision Disorders Using Organoid Single-Cell Multi-omics.
- Source :
-
Neuron [Neuron] 2020 Sep 23; Vol. 107 (6), pp. 1000-1013. - Publication Year :
- 2020
-
Abstract
- Human organoid models of the central nervous system, including the neural retina, are providing unprecedented opportunities to explore human neurodevelopment and neurodegeneration in controlled culture environments. In this Perspective, we discuss how the single-cell multi-omic toolkit has been used to identify features and limitations of brain and retina organoids and how these tools can be deployed to study congenital brain malformations and vision disorders in organoids. We also address how to improve brain and retina organoid protocols to revolutionize in vitro disease modeling.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Neurodevelopmental Disorders genetics
Neurodevelopmental Disorders pathology
Organoids growth & development
Organoids pathology
Vision Disorders genetics
Vision Disorders pathology
Genomics methods
Neurodevelopmental Disorders metabolism
Organoids metabolism
Primary Cell Culture methods
Single-Cell Analysis methods
Vision Disorders metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 107
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 32970995
- Full Text :
- https://doi.org/10.1016/j.neuron.2020.09.001