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Comparison between the histopathological and immunophenotypical features of hypopigmented and nonhypopigmented mycosis fungoides: A retrospective study.
- Source :
-
Journal of cutaneous pathology [J Cutan Pathol] 2021 Apr; Vol. 48 (4), pp. 486-494. Date of Electronic Publication: 2020 Oct 29. - Publication Year :
- 2021
-
Abstract
- Background: Mycosis fungoides (MF), the commonest primary cutaneous T-cell lymphoma, has classic and variant types which include hypopigmented MF (HMF). Previous studies have identified distinct clinicopathological profiles in HMF. This study aims to objectively compare the clinicopathological features of HMF with non-HMF lesions in order to characterize salient features of HMF.<br />Methods: This cross-sectional, retrospective study analyzed biopsy specimens of 87 patients with MF. HMF and non-HMF groups were compared using clinical data, immunophenotypic features and scores given for six histopathological features: dermal infiltrate, basilar and superficially extending epidermotropism, Pautrier microabscesses and dermal and epidermotropic lymphocytic atypia.<br />Results: Seventy-six patients had HMF. Presentation in females (59.21%; p = .04) and patch stage (88.16%; p = .01) in HMF were significant, and HMF presented at a younger mean age when compared to non-HMF. Both groups had equal intensity of epidermotropism, with HMF showing milder dermal infiltrates and significantly less dermal atypia. Pautrier microabscesses were significantly commoner in non-HMF (LR 10.76; pā<ā.01). 94.74% of HMF were CD4-/CD8+.<br />Conclusion: HMF presents at a lower age and earlier stage with female predominance compared to non-HMF. Because of milder dermal infiltrates, less dermal atypia, and Pautrier microabscesses, the diagnosis of HMF requires correlation with clinical features and careful assessment of epidermotropic cells.<br /> (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Adult
Biopsy
CD8-Positive T-Lymphocytes pathology
Child
Child, Preschool
Cross-Sectional Studies
Epidermis immunology
Epidermis microbiology
Female
Humans
Infant
Infant, Newborn
Lymphoma, T-Cell, Cutaneous pathology
Male
Middle Aged
Mycosis Fungoides pathology
Mycosis Fungoides ultrastructure
Pigmentation Disorders pathology
Retrospective Studies
Young Adult
Epidermis pathology
Immunophenotyping methods
Mycosis Fungoides diagnosis
Mycosis Fungoides genetics
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0560
- Volume :
- 48
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of cutaneous pathology
- Publication Type :
- Academic Journal
- Accession number :
- 32965737
- Full Text :
- https://doi.org/10.1111/cup.13882