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Water dispersible ZnSe/ZnS quantum dots: Assessment of cellular integration, toxicity and bio-distribution.
- Source :
-
Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2020 Nov; Vol. 212, pp. 112019. Date of Electronic Publication: 2020 Sep 12. - Publication Year :
- 2020
-
Abstract
- Quantum dots (QDs) comprise an emerging group of materials with innumerable number of possibilities in biological research including cellular labelling. Among the leading members in this category, ZnSe/ZnS quantum dots (QDs) hold greater attractive possibilities in imaging primarily due to their higher biocompatibility and dispersibility. Nevertheless, the inherent toxicity of ZnSe/ZnS QDs is not yet completely explored which largely compromise most of their biomedical application potential. Strong blue emitting water soluble QDs effectively synthesized by aqueous phase route. Synthesized QDs further subjected to various optical and physicochemical characterization. Approximately 5-6 nm sized ZnSe/ZnS QDs illuminated bluish green fluorescence under UV lamp. Present study addresses possible adverse effects of ZnSe/ZnS QDs in hepatic system using HepG2 cells; which is the routinely employed in vitroliver cell model. A bundle of assays wasperformed out to reveal the cytotoxic nature of ZnSe/ZnS QDs and the mechanism behind it. Herein, absorption, distribution, metabolism, excretion and toxicity (ADME and T) of ZnSe/ZnS in mice were profiled in detail followed by intravenous (i.v.) and intraperitoneal (i.p.) administration at a dose of 10 mg/kg body weight. In a short review, it could be state that ZnSe/ZnS QDs did not exhibit any significant in vivo toxicity outcome in mice.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Cytoplasm drug effects
Cytoplasm metabolism
Hep G2 Cells
Humans
Lysosomes drug effects
Lysosomes metabolism
Membrane Potential, Mitochondrial drug effects
Mice
Sulfides metabolism
Sulfides pharmacokinetics
Sulfides toxicity
Tissue Distribution
Zinc Compounds metabolism
Zinc Compounds pharmacokinetics
Zinc Compounds toxicity
Quantum Dots toxicity
Selenium Compounds chemistry
Sulfides chemistry
Water chemistry
Zinc Compounds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2682
- Volume :
- 212
- Database :
- MEDLINE
- Journal :
- Journal of photochemistry and photobiology. B, Biology
- Publication Type :
- Academic Journal
- Accession number :
- 32957068
- Full Text :
- https://doi.org/10.1016/j.jphotobiol.2020.112019