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Antivitamins B 12 -Some Inaugural Milestones.

Authors :
Kräutler B
Source :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Dec 01; Vol. 26 (67), pp. 15438-15445. Date of Electronic Publication: 2020 Nov 03.
Publication Year :
2020

Abstract

The recently delineated structure- and reactivity-based concept of antivitamins B <subscript>12</subscript> has begun to bear fruit by the generation, and study, of a range of such B <subscript>12</subscript> -dummies, either vitamin B <subscript>12</subscript> -derived, or transition metal analogues that also represent potential antivitamins B <subscript>12</subscript> or specific B <subscript>12</subscript> -antimetabolites. As reviewed here, this has opened up new research avenues in organometallic B <subscript>12</subscript> -chemistry and bioinorganic coordination chemistry. Exploratory studies with antivitamins B <subscript>12</subscript> have, furthermore, revealed some of their potential, as pharmacologically interesting compounds, for inducing B <subscript>12</subscript> -deficiency in a range of organisms, from hospital resistant bacteria to laboratory mice. The derived capacity of antivitamins B <subscript>12</subscript> to induce functional B <subscript>12</subscript> -deficiency in mammalian cells and organs also suggest their valuable potential as growth inhibitors of cancerous human and animal cells.<br /> (© 2020 The Authors. Published by Wiley-VCH GmbH.)

Details

Language :
English
ISSN :
1521-3765
Volume :
26
Issue :
67
Database :
MEDLINE
Journal :
Chemistry (Weinheim an der Bergstrasse, Germany)
Publication Type :
Academic Journal
Accession number :
32956545
Full Text :
https://doi.org/10.1002/chem.202003788