Back to Search
Start Over
PARTICULATE MATTER FROM SYRINGES USED FOR INTRAVITREAL INJECTIONS.
- Source :
-
Retina (Philadelphia, Pa.) [Retina] 2021 Apr 01; Vol. 41 (4), pp. 827-833. - Publication Year :
- 2021
-
Abstract
- Background: Syringes containing anti-vascular endothelial growth factor drugs to treat retinal diseases are prepared in different ways by various parties with syringe selection, preparation, and storage conditions affecting the risk of injecting particles into the vitreous. This study examines particle loads from various syringes over time.<br />Methods: Four syringes were studied: two plastic transfer syringes lubricated with silicone oil or oleamide, a glass syringe with baked-on silicone, and a lubricant-free polymer syringe. Syringes were rinsed with water or filled with buffer and analyzed over time; particles were quantified by flow imaging. Particle formation in a bevacizumab formulation was also characterized.<br />Results: Insulin syringes consistently showed very high particle counts. Oleamide-lubricated syringes had substantially fewer particles, but showed appreciable increases over time (leading to visible particles). Baked-on silicone glass syringes and lubricant-free polymer syringes both showed low particle levels ≥10 μm. Lubricant-free syringes showed the lowest particle levels ≥1 μm and the lowest particle levels with bevacizumab agitation.<br />Conclusion: Syringes have different intrinsic particle loads which can contribute to particle loads in the delivered drug. Oleamide-lubricated transfer syringes, commonly used for bevacizumab repackaging, have time-dependent particle loads and are associated with the formation of visible particles beyond 30 days of storage.<br /> (Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Opthalmic Communications Society, Inc.)
- Subjects :
- Drug Packaging
Intravitreal Injections
Lubricants
Protein Aggregation, Pathological diagnosis
Protein Aggregation, Pathological metabolism
Silicone Oils chemistry
Vascular Endothelial Growth Factor A antagonists & inhibitors
Angiogenesis Inhibitors metabolism
Bevacizumab metabolism
Drug Compounding methods
Particulate Matter metabolism
Protein Aggregation, Pathological etiology
Syringes
Subjects
Details
- Language :
- English
- ISSN :
- 1539-2864
- Volume :
- 41
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Retina (Philadelphia, Pa.)
- Publication Type :
- Academic Journal
- Accession number :
- 32956210
- Full Text :
- https://doi.org/10.1097/IAE.0000000000002947