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Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns.
- Source :
-
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2021 May; Vol. 41 (5), pp. 1162-1174. Date of Electronic Publication: 2020 Sep 21. - Publication Year :
- 2021
-
Abstract
- White matter hyperintensities (WMHs) are associated with vascular risk and Alzheimer's disease. In this study, we examined relations between WMH load and distribution, amyloid pathology and vascular risk in 339 controls and cases with either subjective (SCD) or mild cognitive impairment (MCI). Regional deep (DWMH) and periventricular (PWMH) WMH loads were determined using an automated algorithm. We stratified on Aβ1-42 pathology (Aβ+/-) and analyzed group differences, as well as associations with Framingham Risk Score for cardiovascular disease (FRS-CVD) and age. Occipital PWMH ( p = 0.001) and occipital DWMH ( p = 0.003) loads were increased in SCD-Aβ+ compared with Aβ- controls. In MCI-Aβ+ compared with Aβ- controls, there were differences in global WMH ( p = 0.003), as well as occipital DWMH ( p = 0.001) and temporal DWMH ( p = 0.002) loads. FRS-CVD was associated with frontal PWMHs ( p = 0.003) and frontal DWMHs ( p = 0.005), after adjusting for age. There were associations between global and all regional WMH loads and age. In summary, posterior WMH loads were increased in SCD-Aβ+ and MCI-Aβ+ cases, whereas frontal WMHs were associated with vascular risk. The differences in WMH topography support the use of regional WMH load as an early-stage marker of etiology.
- Subjects :
- Adult
Aged
Aged, 80 and over
Algorithms
Alzheimer Disease etiology
Alzheimer Disease pathology
Amyloid cerebrospinal fluid
Brain diagnostic imaging
Case-Control Studies
Cerebrospinal Fluid metabolism
Cognitive Dysfunction diagnosis
Female
Frontal Lobe diagnostic imaging
Frontal Lobe pathology
Heart Disease Risk Factors
Humans
Leukoaraiosis diagnostic imaging
Longitudinal Studies
Magnetic Resonance Imaging methods
Male
Middle Aged
Neuropsychological Tests standards
Norway epidemiology
Occipital Lobe diagnostic imaging
Occipital Lobe pathology
Temporal Lobe diagnostic imaging
Temporal Lobe pathology
Vascular Diseases complications
White Matter diagnostic imaging
Amyloid metabolism
Brain pathology
Cognitive Dysfunction etiology
Leukoaraiosis pathology
White Matter pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1559-7016
- Volume :
- 41
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 32955960
- Full Text :
- https://doi.org/10.1177/0271678X20957604