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Lymphocytic Colitis With Increased Apoptosis: A Marker of Mutation in T-Cell-Mediated Immunity?
- Source :
-
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society [Pediatr Dev Pathol] 2020 Nov-Dec; Vol. 23 (6), pp. 443-447. Date of Electronic Publication: 2020 Sep 21. - Publication Year :
- 2020
-
Abstract
- Lymphocytic colitis is a subtype of microscopic colitis that is mostly seen in adults. It presents mainly as chronic nonbloody diarrhea, with the hallmark of normal or near-normal endoscopy. In this case series, we are presenting 4 pediatric patients with lymphocytic colitis with prominent apoptosis of the colonic gland epithelium. Remarkably, all the patients have genetic mutations known to be associated with autoimmune enteropathy. Three patients have a CTLA4 mutation, and 1 patient has an STAT3 mutation. These mutations were previously reported in association with inflammatory bowel disease, but a specific connection with lymphocytic colitis has not been described. This report investigates the histopathology of such lesions in children and adolescents.
- Subjects :
- Adolescent
Apoptosis
Child
Colitis, Lymphocytic genetics
Colitis, Lymphocytic immunology
Colon immunology
Genetic Markers
Humans
Intestinal Mucosa immunology
Male
CTLA-4 Antigen genetics
Colitis, Lymphocytic pathology
Colon pathology
Immunity, Cellular
Intestinal Mucosa pathology
Mutation
STAT3 Transcription Factor genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1615-5742
- Volume :
- 23
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
- Publication Type :
- Academic Journal
- Accession number :
- 32955408
- Full Text :
- https://doi.org/10.1177/1093526620959054