HDR brachytherapy well chamber calibration and stability evaluated over twenty years of clinical use.

Purpose: The purpose of the study was to establish, using a retrospective analysis of existing hospital records, the long-term stability and accuracy of a high-dose-rate brachytherapy well chamber. This should be assessed to determine reliability and appropriate calibration frequency. The accrual of long-term data that demonstrates the stability of our chamber may inform others of the performance they might expect from similar equipment.
Methods and Materials: We evaluated air kerma strength measurements made with the PTW 32002 (Nucletron 077.091) high-dose-rate well chamber on 72 ¹⁹² Ir sources over an 18-year period and the seven calibrations of that chamber which span a 27-year period.
Results: Consecutive air kerma strength measurements agreed within 0.01% on average. The chamber measurement agreed with the source specification within 0.02% on average, but was up to 1.4% during some calibration periods. The chamber calibration coefficient varied by a maximum of 5% over seven chamber calibration measurements.
Conclusions: The constancy of the well chamber current compared with the source manufacturer suggests that our chamber has been stable to better than 2% over a period of 18 years. Although the chamber has received different calibration coefficients over time, these coefficients are within the combined uncertainties of any two calibrations and are consistent with the chamber being stable. The agreement we have observed between clinical measurements and the source manufacturer would justify an action level for further investigation of 1%, for this specific chamber.
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