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Cognitive and hippocampal synaptic profiles in monosodium glutamate-induced obese mice.
- Source :
-
Neuroscience research [Neurosci Res] 2021 Sep; Vol. 170, pp. 201-207. Date of Electronic Publication: 2020 Sep 17. - Publication Year :
- 2021
-
Abstract
- Obesity is a growing worldwide public health issue and is associated with a range of comorbidities, including cognitive deficits. The present study investigated synaptic changes in the hippocampus during the development of obesity. The treatment of newborn mice with monosodium-L-glutamate (MSG, 2 mg/g) induced obesity and recognition memory deficits in the novel object recognition (NOR) test at 16-17 weeks, but not at 8-9 weeks. Hippocampal synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), and excitatory synaptic transmission at Schaffer collateral-CA1 (SC-CA1) synapses were compared between MSG-treated mice and age-matched control mice. LTP and fiber volley amplitudes were enhanced in MSG-treated mice at 16-17 weeks, but not at 8-9 weeks. Furthermore, the strength of paired-pulse facilitation (PPF) changed in MSG-treated mice at 16-17 weeks, but not at 8-9 weeks. These results suggest that enhanced LTP in the SC-CA1 synapses of MSG-induced obese mice involves presynaptic rather than postsynaptic mechanisms.<br />Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest.<br /> (Copyright © 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1872-8111
- Volume :
- 170
- Database :
- MEDLINE
- Journal :
- Neuroscience research
- Publication Type :
- Academic Journal
- Accession number :
- 32949668
- Full Text :
- https://doi.org/10.1016/j.neures.2020.08.005