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Hypercytokinemia in COVID-19: Tear cytokine profile in hospitalized COVID-19 patients.
- Source :
-
Experimental eye research [Exp Eye Res] 2020 Nov; Vol. 200, pp. 108253. Date of Electronic Publication: 2020 Sep 16. - Publication Year :
- 2020
-
Abstract
- The aim of this study is to analyze the concentrations of cytokines in tear of hospitalized COVID-19 patients compared to healthy controls. Tear samples were obtained from 41 healthy controls and 62 COVID-19 patients. Twenty-seven cytokines were assessed: interleukin (IL)-1b, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL9, IL-10, IL-12, IL-13, IL-15, IL-17, eotaxin, fibroblast growth factor basic, granulocyte colony-stimulating factor (G-CSF), granulocyte-monocyte colony-stimulating factor (GM-CSF), interferon (IFN)-γ, interferon gamma-induced protein, monocyte chemo-attractant protein-1, macrophage inflammatory protein (MIP)-1a, MIP-1b, platelet-derived growth factor (PDGF), regulated on activation normal T cell expressed and secreted, tumor necrosis factor-α and vascular endothelial growth factor (VEGF). In tear samples of COVID-19 patients, an increase in IL-9, IL-15, G-CSF, GM-CSF, IFN-γ, PDGF and VEGF was observed, along with a decrease in eotaxin compared to the control group (p < 0.05). A poor correlation between IL-6 levels in tear and blood was found. IL-1RA and GM-CSF were significantly lower in severe patients and those who needed treatment targeting the immune system (p < 0.05). Tear cytokine levels corroborate the inflammatory nature of SARS-CoV-2.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
COVID-19
Coronavirus Infections classification
Coronavirus Infections diagnosis
Cross-Sectional Studies
Female
Hospitalization
Humans
Immunoassay
Inflammation metabolism
Keratitis metabolism
Luminescent Measurements
Male
Middle Aged
Pandemics classification
Pneumonia, Viral classification
Pneumonia, Viral diagnosis
Real-Time Polymerase Chain Reaction
SARS-CoV-2
Tertiary Care Centers
Betacoronavirus
Coronavirus Infections metabolism
Cytokines metabolism
Eye Proteins metabolism
Pneumonia, Viral metabolism
Tears metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0007
- Volume :
- 200
- Database :
- MEDLINE
- Journal :
- Experimental eye research
- Publication Type :
- Academic Journal
- Accession number :
- 32949577
- Full Text :
- https://doi.org/10.1016/j.exer.2020.108253