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Outcomes in infants < 29 weeks of gestation following single-dose prophylactic indomethacin.
- Source :
-
Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2021 Jan; Vol. 41 (1), pp. 109-118. Date of Electronic Publication: 2020 Sep 18. - Publication Year :
- 2021
-
Abstract
- Background: Prophylactic indomethacin (3 doses) decreases patent ductus arteriosus (PDA) and intraventricular hemorrhage (IVH) in preterm infants. The study aim was to determine whether single-dose indomethacin (SD-INDO) decreases PDA, IVH, and improves motor function.<br />Methods: A retrospective cohort (2007-2014) compared infants born < 29 weeks who did (n = 299) or did not (n = 85) receive SD-INDO and estimated outcomes association with ordinal logistic regression, adjusting for multiple variables using propensity scores.<br />Results: Infants who received SD-INDO were more premature (p < 0.001) but had lower odds of PDA (OR 0.26 [0.15, 0.44], p < 0.005), PDA receiving treatment (OR 0.12 [0.03, 0.47], p < 0.005), death (OR 0.41 [0.20, 0.86], p = 0.02), and CP severity (OR 0.33 [0.12, 0.89], p = 0.03). There was less IVH (OR 0.58 [0.36, 0.94], p = 0.03) when adjusted for gestational age.<br />Conclusions: SD-INDO is associated with decreased PDA and CP severity and improved survival.
Details
- Language :
- English
- ISSN :
- 1476-5543
- Volume :
- 41
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of perinatology : official journal of the California Perinatal Association
- Publication Type :
- Academic Journal
- Accession number :
- 32948814
- Full Text :
- https://doi.org/10.1038/s41372-020-00814-9