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New indole alkaloids from the seeds of Datura metel L.
- Source :
-
Fitoterapia [Fitoterapia] 2020 Oct; Vol. 146, pp. 104726. Date of Electronic Publication: 2020 Sep 16. - Publication Year :
- 2020
-
Abstract
- Four new indole alkaloids, daturametelindoles A-D (1-4) were isolated from the EtOAc soluble partition of the ethanol extract of the Datura metel seeds. The structures of the new compounds were determined based on spectroscopic evidence, including their 1D- and 2D-NMR spectra and mass spectrometry. In particular, compounds 1-4 were all racemes, confirmed by the optical rotations and CD spectra. Unfortunately, the chiral monomers were not obtained due to the amount, but the developments of their chiral separation and chiral resolution were completed. All isolated compounds were evaluated for cytotoxic effects against human gastric adenocarcinoma cells (SGC-7901), human hepatoma (Hepg2), and human breast cancer (MCF-7).<br />Competing Interests: Declaration of Competing Interest The authors of this manuscript have declared that no competing interests exist.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Antineoplastic Agents, Phytogenic isolation & purification
Cell Line, Tumor
China
Humans
Indole Alkaloids isolation & purification
Molecular Structure
Phytochemicals isolation & purification
Phytochemicals pharmacology
Antineoplastic Agents, Phytogenic pharmacology
Datura metel chemistry
Indole Alkaloids pharmacology
Seeds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 146
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 32946946
- Full Text :
- https://doi.org/10.1016/j.fitote.2020.104726