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Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [ 11 C]UCB-J positron emission tomography study.
- Source :
-
Epilepsia [Epilepsia] 2020 Oct; Vol. 61 (10), pp. 2183-2193. Date of Electronic Publication: 2020 Sep 18. - Publication Year :
- 2020
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Abstract
- Objective: In this positron emission tomography (PET) study with [ <superscript>11</superscript> C]UCB-J, we evaluated synaptic vesicle glycoprotein 2A (SV2A) binding, which is decreased in resected brain tissues from epilepsy patients, in subjects with temporal lobe epilepsy (TLE) and compared the regional binding pattern to [ <superscript>18</superscript> F]fluorodeoxyglucose (FDG) uptake.<br />Methods: Twelve TLE subjects and 12 control subjects were examined. Regional [ <superscript>11</superscript> C]UCB-J binding potential (BP <subscript>ND</subscript> ) values were estimated using the centrum semiovale as a reference region. [ <superscript>18</superscript> F]FDG uptake in TLE subjects was quantified using mean radioactivity values. Asymmetry in outcome measures was assessed by comparison of ipsilateral and contralateral regions. Partial volume correction (PVC) with the iterative Yang algorithm was applied based on the FreeSurfer segmentation.<br />Results: In 11 TLE subjects with medial temporal lobe sclerosis (MTS), the hippocampal volumetric asymmetry was 25 ± 11%. After PVC, [ <superscript>11</superscript> C]UCB-J BP <subscript>ND</subscript> asymmetry indices were 37 ± 19% in the hippocampus, with very limited asymmetry in other brain regions. Reductions in [ <superscript>11</superscript> C]UCB-J BP <subscript>ND</subscript> values were restricted to the sclerotic hippocampus when compared to control subjects. The corresponding asymmetry in hippocampal [ <superscript>18</superscript> F]FDG uptake was 22 ± 7% and correlated with that of [ <superscript>11</superscript> C]UCB-J BP <subscript>ND</subscript> across subjects (R <superscript>2</superscript>  = .38). Hippocampal asymmetries in [ <superscript>11</superscript> C]UCB-J binding were 1.7-fold larger than those of [ <superscript>18</superscript> F]FDG uptake.<br />Significance: [ <superscript>11</superscript> C]UCB-J binding is reduced in the seizure onset zone of TLE subjects with MTS. PET imaging of SV2A may be a promising biomarker approach in the presurgical selection and evaluation of TLE patients and may improve the sensitivity of molecular imaging for seizure focus detection.<br /> (© 2020 International League Against Epilepsy.)
- Subjects :
- Adult
Carbon Radioisotopes metabolism
Female
Fluorodeoxyglucose F18 metabolism
Hippocampus diagnostic imaging
Hippocampus metabolism
Humans
Male
Middle Aged
Protein Binding physiology
Temporal Lobe diagnostic imaging
Temporal Lobe metabolism
Young Adult
Epilepsy, Temporal Lobe diagnostic imaging
Epilepsy, Temporal Lobe metabolism
Membrane Glycoproteins metabolism
Nerve Tissue Proteins metabolism
Positron-Emission Tomography methods
Pyridines metabolism
Pyrrolidinones metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1528-1167
- Volume :
- 61
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Epilepsia
- Publication Type :
- Academic Journal
- Accession number :
- 32944949
- Full Text :
- https://doi.org/10.1111/epi.16653