Back to Search
Start Over
Disorders of IGFs and IGF-1R signaling pathways.
- Source :
-
Molecular and cellular endocrinology [Mol Cell Endocrinol] 2020 Dec 01; Vol. 518, pp. 111035. Date of Electronic Publication: 2020 Sep 15. - Publication Year :
- 2020
-
Abstract
- The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that regulate multiple physiological processes, including mammalian development, metabolism and growth, through the type 1 IGF receptor (IGF-1R). The growth hormone (GH)-IGF-I axis is the major regulator of longitudinal growth. IGF-II is expressed in many tissues, notably the placenta, to regulate human pre- and post-natal growth and development. This review provides a brief introduction to the IGF system and summarizes findings from reports arising from recent larger genomic sequencing studies of human genetic mutations in IGF1 and IGF2 and genes of proteins regulating IGF action, namely the IGF-1R, IGF-1R signaling pathway components and the IGF binding proteins (IGFBPs). A perspective on the effect of homozygous mutations on structure and function of the IGFs and IGF-1R is also given and this is related to the effects on growth.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Female
Genetic Diseases, Inborn genetics
Genetic Diseases, Inborn metabolism
Growth Disorders metabolism
Humans
Metabolic Diseases metabolism
Mutation
Pregnancy
Receptor, IGF Type 1 genetics
Receptor, IGF Type 1 physiology
Receptors, Somatomedin physiology
Signal Transduction physiology
Somatomedins physiology
Growth Disorders genetics
Metabolic Diseases genetics
Receptors, Somatomedin genetics
Somatomedins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8057
- Volume :
- 518
- Database :
- MEDLINE
- Journal :
- Molecular and cellular endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 32941924
- Full Text :
- https://doi.org/10.1016/j.mce.2020.111035