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Postoperative Administration of the Acetylcholinesterase Inhibitor, Donepezil, Interferes with Bone Healing and Implant Osseointegration in a Rat Model.
- Source :
-
Biomolecules [Biomolecules] 2020 Sep 14; Vol. 10 (9). Date of Electronic Publication: 2020 Sep 14. - Publication Year :
- 2020
-
Abstract
- Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer's disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration of donepezil on bone healing remains unknown. Therefore, this study aimed to assess the impact of postoperative injection of donepezil on bone healing, titanium-implant osseointegration, and soft tissue healing. Twenty-two Sprague-Dawley rats were randomly assigned to receive a daily dose of either donepezil (0.6 mg/kg) or saline as a control. In each rat, a uni-cortical defect was created in the right tibia metaphysis and a custom-made titanium implant was placed in the left tibiae. After two weeks, rats were euthanized, and their bones were analysed by Micro-CT and histology. The healing of bone defect and implant osseointegration in the rats treated with donepezil were significantly reduced compared to the saline-treated rats. Histomorphometric analysis showed lower immune cell infiltration in bone defects treated with donepezil compared to the saline-treated defects. On the other hand, the healing time of soft tissue wounds was significantly shorter in donepezil-treated rats compared to the controls. In conclusion, short-term administration of donepezil hinders bone healing whereas enhancing soft tissue healing.
- Subjects :
- Animals
Bone Substitutes chemistry
Bone-Implant Interface diagnostic imaging
Female
Rats
Rats, Sprague-Dawley
Tibia diagnostic imaging
Tibia drug effects
Tibia injuries
Tibial Fractures diagnostic imaging
Titanium chemistry
X-Ray Microtomography
Bone-Implant Interface pathology
Cholinesterase Inhibitors adverse effects
Donepezil adverse effects
Osseointegration drug effects
Tibial Fractures pathology
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2218-273X
- Volume :
- 10
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Biomolecules
- Publication Type :
- Academic Journal
- Accession number :
- 32937955
- Full Text :
- https://doi.org/10.3390/biom10091318