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Regulation of p27 Kip1 and p57 Kip2 Functions by Natural Polyphenols.
- Source :
-
Biomolecules [Biomolecules] 2020 Sep 13; Vol. 10 (9). Date of Electronic Publication: 2020 Sep 13. - Publication Year :
- 2020
-
Abstract
- In numerous instances, the fate of a single cell not only represents its peculiar outcome but also contributes to the overall status of an organism. In turn, the cell division cycle and its control strongly influence cell destiny, playing a critical role in targeting it towards a specific phenotype. Several factors participate in the control of growth, and among them, p27 <superscript>Kip1</superscript> and p57 <superscript>Kip2</superscript> , two proteins modulating various transitions of the cell cycle, appear to play key functions. In this review, the major features of p27 and p57 will be described, focusing, in particular, on their recently identified roles not directly correlated with cell cycle modulation. Then, their possible roles as molecular effectors of polyphenols' activities will be discussed. Polyphenols represent a large family of natural bioactive molecules that have been demonstrated to exhibit promising protective activities against several human diseases. Their use has also been proposed in association with classical therapies for improving their clinical effects and for diminishing their negative side activities. The importance of p27 <superscript>Kip1</superscript> and p57 <superscript>Kip2</superscript> in polyphenols' cellular effects will be discussed with the aim of identifying novel therapeutic strategies for the treatment of important human diseases, such as cancers, characterized by an altered control of growth.
- Subjects :
- Catechin pharmacology
Cell Cycle drug effects
Cell Cycle genetics
Cell Line, Tumor
Cell Nucleus drug effects
Cell Nucleus metabolism
Cyclin-Dependent Kinase Inhibitor p27 metabolism
Cyclin-Dependent Kinase Inhibitor p57 metabolism
Cytoplasm drug effects
Cytoplasm metabolism
Gene Expression Regulation, Neoplastic
Humans
Neoplasms genetics
Neoplasms metabolism
Neoplasms pathology
Proteasome Endopeptidase Complex drug effects
Proteasome Endopeptidase Complex metabolism
Protein Domains
Proteolysis
Antineoplastic Agents, Phytogenic pharmacology
Catechin analogs & derivatives
Cyclin-Dependent Kinase Inhibitor p27 genetics
Cyclin-Dependent Kinase Inhibitor p57 genetics
Neoplasms drug therapy
Resveratrol pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2218-273X
- Volume :
- 10
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Biomolecules
- Publication Type :
- Academic Journal
- Accession number :
- 32933137
- Full Text :
- https://doi.org/10.3390/biom10091316