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Population-based analysis on the effect of nodal and distant metastases in sinonasal adenocarcinoma.
- Source :
-
Head & neck [Head Neck] 2021 Jan; Vol. 43 (1), pp. 128-136. Date of Electronic Publication: 2020 Sep 15. - Publication Year :
- 2021
-
Abstract
- Background: Minimal information has been reported on the effect of distant and nodal metastases at the time of diagnosis on survival in patients with sinonasal adenocarcinoma (SNAC).<br />Methods: The Surveillance, Epidemiology, and End Results database was utilized to compare overall survival (OS) and disease-specific survival (DSS).<br />Results: Of the 325 patients with SNAC identified, 5-year and 10-year OS for all included patients was 64% and 58%, respectively. On multivariate analysis, the presence of distant metastases (Pā<ā.0001), maxillary and frontal sinus primary tumors (P = .0042, P = .0006), and increasing age (P = .007) were risk factors for worsened DSS. The presence of regional spread to multiple cervical nodal basins (OS RR 3.26, P = .002; DSS RR 2.51, P = .013) and a single nodal basin (DSS RR 2.19, P = .046) was associated with worsened survival compared to no regional spread.<br />Conclusion: Survival in SNAC was significantly worsened with increasing age, tumor site of origin, and distant metastatic disease.<br /> (© 2020 Wiley Periodicals LLC.)
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 43
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 32929799
- Full Text :
- https://doi.org/10.1002/hed.26457