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Role of gut microbiota in identification of novel TCM-derived active metabolites.

Authors :
Lin TL
Lu CC
Lai WF
Wu TS
Lu JJ
Chen YM
Tzeng CM
Liu HT
Wei H
Lai HC
Source :
Protein & cell [Protein Cell] 2021 May; Vol. 12 (5), pp. 394-410. Date of Electronic Publication: 2020 Sep 15.
Publication Year :
2021

Abstract

Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by the host, but rather enter the intestine to be transformed by gut microbiota. The gut microbiota is a microbial community living in animal intestines, and functions to maintain host homeostasis and health. Increasing evidences indicate that TCM herbs closely affect gut microbiota composition, which is associated with the conversion of herbal components into active metabolites. These may significantly affect the therapeutic activity of TCMs. Microbiota analyses, in conjunction with modern multiomics platforms, can together identify novel functional metabolites and form the basis of future TCM research.

Details

Language :
English
ISSN :
1674-8018
Volume :
12
Issue :
5
Database :
MEDLINE
Journal :
Protein & cell
Publication Type :
Academic Journal
Accession number :
32929698
Full Text :
https://doi.org/10.1007/s13238-020-00784-w