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Octreotide for resuscitation of cardiac arrest due to carcinoid crisis precipitated by novel peptide receptor radionuclide therapy (PRRT): A case report.
- Source :
-
Journal of critical care [J Crit Care] 2020 Dec; Vol. 60, pp. 319-322. Date of Electronic Publication: 2020 Aug 17. - Publication Year :
- 2020
-
Abstract
- Peptide receptor radionuclide therapy (PRRT) is an effective treatment for metastatic carcinoid tumours but can precipitate a carcinoid crisis through release of stored bioamines. Cardiac arrest is an uncommon manifestation of carcinoid crisis and has never been reported as a complication of PRRT. We report a case of a 58-year old female who suffered from cardiac arrest following PRRT for metastatic carcinoid tumour. She was successfully resuscitated using intravenous octreotide following 22 min of failure to resuscitate with a standard advanced cardiac life support protocol. Following resuscitation, severe carcinoid heart disease was diagnosed, and the patient subsequently underwent successful surgical valve replacement. Although there is no trial evidence, considering pharmacological rationale and successful outcome in this case, we suggest early administration of intravenous octreotide during resuscitation of patients suffering cardiac arrest post PRRT for carcinoid disease and recommend preventive strategies.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Carcinoid Tumor secondary
Disease Progression
Female
Follow-Up Studies
Humans
Intestinal Neoplasms pathology
Intestinal Neoplasms surgery
Middle Aged
Neuroendocrine Tumors pathology
Neuroendocrine Tumors surgery
Octreotide therapeutic use
Treatment Outcome
Antineoplastic Agents, Hormonal therapeutic use
Carcinoid Tumor radiotherapy
Heart Arrest drug therapy
Octreotide analogs & derivatives
Organometallic Compounds therapeutic use
Radiopharmaceuticals therapeutic use
Resuscitation methods
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8615
- Volume :
- 60
- Database :
- MEDLINE
- Journal :
- Journal of critical care
- Publication Type :
- Report
- Accession number :
- 32928590
- Full Text :
- https://doi.org/10.1016/j.jcrc.2020.08.011