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The importance of virion-incorporated cellular RNA-Binding Proteins in viral particle assembly and infectivity.
- Source :
-
Seminars in cell & developmental biology [Semin Cell Dev Biol] 2021 Mar; Vol. 111, pp. 108-118. Date of Electronic Publication: 2020 Sep 10. - Publication Year :
- 2021
-
Abstract
- RNA is a central molecule in RNA virus biology due to its dual function as messenger and genome. However, the small number of proteins encoded by viral genomes is insufficient to enable virus infection. Hence, viruses hijack cellular RNA-binding proteins (RBPs) to aid replication and spread. In this review we discuss the 'knowns' and 'unknowns' regarding the contribution of host RBPs to the formation of viral particles and the initial steps of infection in the newly infected cell. Through comparison of the virion proteomes of ten different human RNA viruses, we confirm that a pool of cellular RBPs are typically incorporated into viral particles. We describe here illustrative examples supporting the important functions of these RBPs in viral particle formation and infectivity and we propose that the role of host RBPs in these steps can be broader than previously anticipated. Understanding how cellular RBPs regulate virus infection can lead to the discovery of novel therapeutic targets against viruses.<br /> (Copyright © 2020. Published by Elsevier Ltd.)
- Subjects :
- Gene Expression Regulation
Host-Pathogen Interactions genetics
Humans
Protein Binding
Protein Biosynthesis
RNA, Messenger metabolism
RNA, Viral metabolism
RNA-Binding Proteins metabolism
Ribosomes genetics
Ribosomes metabolism
Signal Transduction
Viral Proteins metabolism
Virion growth & development
Virion metabolism
Virus Assembly
Virus Diseases metabolism
Virus Diseases pathology
Virus Diseases virology
Virus Replication
Viruses classification
Viruses growth & development
Viruses pathogenicity
RNA, Messenger genetics
RNA, Viral genetics
RNA-Binding Proteins genetics
Viral Proteins genetics
Virion genetics
Virus Diseases genetics
Viruses genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1096-3634
- Volume :
- 111
- Database :
- MEDLINE
- Journal :
- Seminars in cell & developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 32921578
- Full Text :
- https://doi.org/10.1016/j.semcdb.2020.08.002