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Efficacy of argon-helium cryoablation and its effects on immune function of patients with neck malignant tumours.
- Source :
-
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery [Clin Otolaryngol] 2021 Jan; Vol. 46 (1), pp. 206-212. Date of Electronic Publication: 2020 Oct 15. - Publication Year :
- 2021
-
Abstract
- Objectives: Our study aimed to investigate the clinical efficacy of argon-helium cryoablation and its effects on the immune function of patients with neck malignant tumours.<br />Design: Retrospective study.<br />Setting: Single-institution academic tertiary care centre.<br />Methods: Totally, 180 patients harbouring head and neck malignant tumours were divided into the argon-helium cryoablation group (n = 150) and the radiotherapy group (n = 50). The efficacy of the two groups was compared, and the immune function was observed.<br />Results: The short-term clinical effect of the argon-helium cryoablation group was significantly higher than that of the radiotherapy group (P < .05). After treatment, the CD3+, CD4+, CD8+ and CD4+/CD8+ of the argon-helium cryoablation group were significantly better than those of the radiotherapy group (P < .001). The results of TNF-α, IL-1 β and CRP in the argon-helium cryoablation group were significantly better than that in the radiotherapy group (P < .001).<br />Conclusion: Argon-helium cryoablation could effectively improve the immune function, 5-year survival rate and local remission rate.<br /> (© 2020 John Wiley & Sons Ltd.)
- Subjects :
- Adult
C-Reactive Protein metabolism
CD4-CD8 Ratio
Carcinoma immunology
Carcinoma mortality
Female
Head and Neck Neoplasms mortality
Humans
Interleukin-1beta blood
Male
Middle Aged
Retrospective Studies
Treatment Outcome
Tumor Necrosis Factor-alpha blood
Argon
Carcinoma surgery
Cryosurgery
Head and Neck Neoplasms immunology
Head and Neck Neoplasms surgery
Helium
Subjects
Details
- Language :
- English
- ISSN :
- 1749-4486
- Volume :
- 46
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 32920994
- Full Text :
- https://doi.org/10.1111/coa.13648