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Looking for Sunshine: Genetic Predisposition to Sun Seeking in 265,000 Individuals of European Ancestry.
- Source :
-
The Journal of investigative dermatology [J Invest Dermatol] 2021 Apr; Vol. 141 (4), pp. 779-786. Date of Electronic Publication: 2020 Sep 10. - Publication Year :
- 2021
-
Abstract
- Despite growing public awareness of the adverse consequences of excessive sun exposure, modifying sun-seeking behavior is challenging because it appears to be driven by addictive mechanisms. This can have effects on health because sun exposure, although beneficial, when prolonged and repeated shows a causal relationship with skin cancer risk. Using data from 2,500 United Kingdom twins, we observed sun seeking to be significantly heritable (h2 ≥ 58%). In a GWAS meta-analysis of sun-seeking behavior in 261,915 subjects of European ancestry, we identified five GWAS-significant loci previously associated with addiction, behavioral and personality traits, cognitive function, and educational attainment and enriched for CNS gene expression: MIR2113 (P = 2.08 × 10 <superscript>-11</superscript> ), FAM76B/MTMR2/CEP57 (P = 3.70 × 10 <superscript>-9</superscript> ), CADM2 (P = 9.36 × 10 <superscript>-9</superscript> ), TMEM182 (P = 1.64 × 10 <superscript>-8</superscript> ), and PLCL1/LINC01923/SATB2 (P = 3.93 × 10 <superscript>-8</superscript> ). These findings imply that the behavior concerning UV exposure is complicated by a genetic predisposition shared with neuropsychological traits. This should be taken into consideration when designing awareness campaigns and may help improve people's attitudes toward sun exposure.<br /> (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Behavior, Addictive epidemiology
Diseases in Twins epidemiology
Genome-Wide Association Study
Health Knowledge, Attitudes, Practice
Humans
Skin Neoplasms etiology
Skin Neoplasms prevention & control
Social Class
Sunlight adverse effects
United Kingdom epidemiology
White People genetics
Behavior, Addictive genetics
Diseases in Twins genetics
Genetic Predisposition to Disease
Quantitative Trait, Heritable
Sunbathing psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1747
- Volume :
- 141
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of investigative dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 32920024
- Full Text :
- https://doi.org/10.1016/j.jid.2020.08.014