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Appropriate reference region selection of 18 F-florbetaben and 18 F-flutemetamol beta-amyloid PET expressed in Centiloid.
- Source :
-
Scientific reports [Sci Rep] 2020 Sep 11; Vol. 10 (1), pp. 14950. Date of Electronic Publication: 2020 Sep 11. - Publication Year :
- 2020
-
Abstract
- The Centiloid (CL) is a method for standardizing amyloid beta (Aβ) quantification through different ligands and methods. To find the most appropriate reference region to reduce the variance in the Aβ CL unit between <superscript>18</superscript> F-florbetaben (FBB) and <superscript>18</superscript> F-flutemetamol (FMM), we conducted head-to-head comparisons from 56 participants using the direct comparison of FBB-FMM CL (dcCL) method with four reference regions: cerebellar gray (CG), whole cerebellum (WC), WC with brainstem (WC + B), and pons. The FBB and FMM dcCL units were highly correlated in four reference regions: WC (R <superscript>2</superscript> = 0.97), WC + B (R <superscript>2</superscript> = 0.98), CG (R <superscript>2</superscript> = 0.92), and pons (R <superscript>2</superscript> = 0.98). WC showed the largest effect size in both FBB and FMM. Comparison of the variance of the dcCL values within the young control group showed that with FBB, WC + B had the smallest variance and with FMM, the WC had the smallest variance. Additionally, WC + B showed the smallest absolute difference between FBB and FMM, followed by the WC, pons, and CG. We found that it would be reasonable to use the WC or WC + B as the reference region when converting FBB and FMM SUVRs into dcCL, which can increase the accuracy of standardizing FBB and FMM PET results.
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32917930
- Full Text :
- https://doi.org/10.1038/s41598-020-70978-z