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Tissue-Specific Features of Innate Lymphoid Cells.
- Source :
-
Trends in immunology [Trends Immunol] 2020 Oct; Vol. 41 (10), pp. 902-917. Date of Electronic Publication: 2020 Sep 08. - Publication Year :
- 2020
-
Abstract
- Although the function of the circulating immune cell compartment has been studied in detail for decades, limitations in terms of access and cell yields from peripheral tissues have restricted our understanding of tissue-based immunity, particularly in humans. Recent advances in high-throughput protein analyses, transcriptional profiling, and epigenetics have partially overcome these obstacles. Innate lymphoid cells (ILCs) are predominantly tissue-resident, and accumulating data indicate that they have significant tissue-specific functions. We summarize current knowledge of ILC phenotypes in various tissues in mice and humans, aiming to clarify ILC immunity in distinct anatomical locations.<br /> (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1471-4981
- Volume :
- 41
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Trends in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 32917510
- Full Text :
- https://doi.org/10.1016/j.it.2020.08.009