Epigenetic loss of m1A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome.

Authors :: Esteve-Puig R
Climent F
Piñeyro D
Domingo-Domènech E
Davalos V
Encuentra M
Rea A
Espejo-Herrera N
Soler M
Lopez M
Ortiz-Barahona V
Tapia G
Navarro JT
Cid J
Farré L
Villanueva A
Casanova I
Mangues R
Santamarina-Ojeda P
Fernández AF
Fraga MF
Piris MA
Kol N
Avrahami C
Moshitch-Moshkovitz S
Rechavi G
Sureda A
Esteller M
Source :: Blood [Blood] 2021 Feb 18; Vol. 137 (7), pp. 994-999.
Publication Year :: 2021

Subjects :: AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase genetics
AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase metabolism
Base Sequence
Cell Line, Tumor
Collagen Type I genetics
Collagen Type I, alpha 1 Chain
CpG Islands genetics
DNA, Neoplasm genetics
DNA, Neoplasm metabolism
Datasets as Topic
Decitabine pharmacology
Hodgkin Disease genetics
Hodgkin Disease metabolism
Humans
Leukocytes, Mononuclear metabolism
Lymphocytes metabolism
Methylation drug effects
Neoplasm Proteins genetics
Promoter Regions, Genetic genetics
Sequence Alignment
tRNA Methyltransferases metabolism
AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase deficiency
Collagen Type I biosynthesis
DNA Methylation drug effects
Hodgkin Disease enzymology
Neoplasm Proteins metabolism
RNA Interference
RNA Processing, Post-Transcriptional drug effects
RNA, Neoplasm metabolism

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