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Prevalence and Correlates of Intracranial Atherosclerotic Disease Among Community-Dwelling Older Adults of Amerindian Ancestry. The Three Villages Study.
- Source :
-
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2020 Oct; Vol. 29 (10), pp. 105135. Date of Electronic Publication: 2020 Jul 15. - Publication Year :
- 2020
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Abstract
- Background: Knowledge on the prevalence and correlates of intracranial atherosclerotic disease (ICAD) is limited. We aimed to assess prevalence, clinical and neuroimaging correlates of ICAD in a cohort of older adults of Amerindian ancestry.<br />Methods: The study included 581 community-dwellers aged ≥60 years (mean age 71 ± 8.4 years; 57% women) living in rural Ecuadorian villages. ICAD was identified by means of CT determinations of carotid siphon calcifications (CSC) or MRA findings of significant stenosis of intracranial arteries. Fully-adjusted logistic regression models were fitted with biomarkers of ICAD as the dependent variables.<br />Results: A total of 205 (35%) of 581 participants had ICAD, including 185 with high calcium content in the carotid siphons and 40 with significant stenosis of at least one intracranial artery (20 subjects had both biomarkers). Increasing age, high fasting blood glucose, >10 enlarged basal ganglia-perivascular spaces and non-lacunar strokes were associated with high calcium content in the carotid siphons. In contrast, male gender, moderate-to-severe white matter hyperintensities, lacunar and non-lacunar strokes were associated with significant stenosis of intracranial arteries. Stroke was more common among subjects with any biomarker of ICAD than in those with no biomarkers (29% versus 9%, p < 0.001). Significant stenosis of intracranial arteries was more often associated with stroke than high calcium content in the carotid siphons, suggesting that CSC are more likely an ICAD biomarker than causally related to stroke.<br />Conclusions: ICAD prevalence in Amerindians is high, and is significantly associated with stroke. CSC and significant stenosis of intracranial arteries may represent different phenotypes of ICAD.<br />Competing Interests: Declaration of Competing Interest The authors declared they do not have anything to disclose with regards to this study. Dr. José G. Romano is the Principal Investigator of the NIH/NINDS-funded MyRIAD Study (NS084288).<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Age Factors
Aged
Aging ethnology
Comorbidity
Ecuador epidemiology
Female
Health Status
Humans
Intracranial Arteriosclerosis diagnostic imaging
Male
Middle Aged
Prevalence
Risk Assessment
Risk Factors
Stroke diagnostic imaging
Vascular Calcification diagnostic imaging
Independent Living
Indians, South American
Intracranial Arteriosclerosis ethnology
Rural Health ethnology
Stroke ethnology
Vascular Calcification ethnology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8511
- Volume :
- 29
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
- Publication Type :
- Academic Journal
- Accession number :
- 32912521
- Full Text :
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105135