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Calcium, Bioenergetics, and Parkinson's Disease.
- Source :
-
Cells [Cells] 2020 Sep 08; Vol. 9 (9). Date of Electronic Publication: 2020 Sep 08. - Publication Year :
- 2020
-
Abstract
- Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson's disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca <superscript>2+</superscript> oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca <superscript>2+</superscript> oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress.
Details
- Language :
- English
- ISSN :
- 2073-4409
- Volume :
- 9
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Cells
- Publication Type :
- Academic Journal
- Accession number :
- 32911641
- Full Text :
- https://doi.org/10.3390/cells9092045