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Dataset on transcriptomic profiling of cholestatic liver injury in an in vitro and in vivo animal model.

Authors :
Gijbels E
Devisscher L
Vinken M
Source :
Data in brief [Data Brief] 2020 Aug 07; Vol. 32, pp. 106156. Date of Electronic Publication: 2020 Aug 07 (Print Publication: 2020).
Publication Year :
2020

Abstract

The transcriptomic dataset (whole genome microarray Affymetrix Human U133 plus 2.0 and Affymetrix Mouse Genome 430 2.0) presented in this paper describes the differential gene expression profile of a human in vitro model of drug-induced cholestasis and a well-known mouse in vivo model of cholestasis. The in vitro model consists of human hepatoma HepaRG cells in monolayer configuration exposed to 3 different cholestatic drugs with or without bile acids. For in vivo modelling of cholestasis, mice were subjected to bile duct ligation surgery. Consecutive normalization, summarization and background adjustments have been made by means of Robust Multichip Average Express software.<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships which have, or could be perceived to have, influenced the work reported in this article.<br /> (© 2020 The Author(s).)

Details

Language :
English
ISSN :
2352-3409
Volume :
32
Database :
MEDLINE
Journal :
Data in brief
Publication Type :
Academic Journal
Accession number :
32904329
Full Text :
https://doi.org/10.1016/j.dib.2020.106156