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Lack of relation between expression of HLA-DR and secretory component (SC) in follicle-associated epithelium of human Peyer's patches.
- Source :
-
Clinical and experimental immunology [Clin Exp Immunol] 1988 Mar; Vol. 71 (3), pp. 502-7. - Publication Year :
- 1988
-
Abstract
- Follicle-associated epithelium (FAE) of normal human Peyer's patches (PP) was studied with regard to expression of HLA-DR determinants and secretory component (SC); the latter acts as a receptor for polymeric immunoglobulins (pIg). Putative M cells were identified in FAE by lack of a brush border with alkaline phosphatase. These cells were virtually negative for HLA-DR whereas the remaining FAE was strongly positive like villous epithelium. Conversely, the complete FAE showed no SC expression and was negative for IgA. These findings suggested that the FAE (including the M cells) does not participate in SC-mediated transport of pIgA, which in the gut mainly takes place through columnar crypt cells. The FAE (excepting the M cells) may be involved in an MHC class II-restricted antigen-presenting function as recently suggested for villous epithelium. The role of M cells may hence be limited to uptake and transport of luminal antigens.
- Subjects :
- Alkaline Phosphatase metabolism
Epithelium immunology
Fluorescent Antibody Technique
Humans
Immunoglobulin A analysis
Microvilli enzymology
Peyer's Patches enzymology
HLA-D Antigens analysis
HLA-DR Antigens analysis
Immunoglobulin Fragments analysis
Peyer's Patches immunology
Secretory Component analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9104
- Volume :
- 71
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical and experimental immunology
- Publication Type :
- Academic Journal
- Accession number :
- 3289802