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Downregulation of miRNA-429 and upregulation of SOX2 were unfavorable to the prognosis of nasopharyngeal carcinoma.
- Source :
-
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2020 Aug; Vol. 24 (16), pp. 8402-8407. - Publication Year :
- 2020
-
Abstract
- Objective: The purpose of this study was to uncover the correlations of expression levels of microRNA-429 (miRNA-429) and SOX2 with clinical parameters and prognosis of nasopharyngeal carcinoma.<br />Patients and Methods: Nasopharyngeal carcinoma patients (n=95) and nasopharyngitis patients (n=95) in the same period were enrolled. The relative levels of miRNA-429 and SOX2 in nasopharyngeal tissues collected from these patients were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). Then, the potential correlation between miRNA-429 and SOX2 was analyzed by Pearson correlation test. Next, the influences of miRNA-429 and SOX2 levels on clinical parameters of nasopharyngeal carcinoma patients were assessed. At last, the factors influencing the prognosis of nasopharyngeal carcinoma were determined using the Cox regression model.<br />Results: It was found that downregulated miRNA-429 and upregulated SOX2 were observed in nasopharyngeal tissues collected from nasopharyngeal carcinoma patients. MiRNA-429 level was negatively correlated with that of SOX2 in nasopharyngeal carcinoma tissues. In addition, miRNA-429 and SOX2 levels were related to age, tumor differentiation, T stage, N stage, and clinical grade of nasopharyngeal carcinoma patients. Moreover, worse prognosis was seen in nasopharyngeal carcinoma patients expressing low level of miRNA-429 or high level of SOX2. Furthermore, Cox regression analysis showed that T3-T4 stage, moderate to high differentiation, and high level of SOX2 were risk factors, while high level of miRNA-429 was the protective factor for nasopharyngeal carcinoma.<br />Conclusions: Downregulation of miRNA-429 and upregulation of SOX2 are unfavorable to the prognosis of nasopharyngeal carcinoma.
- Subjects :
- Adult
Aged
Female
Humans
Male
MicroRNAs genetics
Middle Aged
Multivariate Analysis
Nasopharyngeal Carcinoma metabolism
Nasopharyngeal Neoplasms metabolism
SOXB1 Transcription Factors genetics
Down-Regulation
MicroRNAs metabolism
Nasopharyngeal Carcinoma diagnosis
Nasopharyngeal Neoplasms diagnosis
SOXB1 Transcription Factors metabolism
Up-Regulation
Subjects
Details
- Language :
- English
- ISSN :
- 2284-0729
- Volume :
- 24
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- European review for medical and pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32894547
- Full Text :
- https://doi.org/10.26355/eurrev_202008_22637