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Fetal growth restriction is a host specific response to infection with an impaired spiral artery remodeling-inducing strain of Porphyromonas gingivalis.
- Source :
-
Scientific reports [Sci Rep] 2020 Sep 03; Vol. 10 (1), pp. 14606. Date of Electronic Publication: 2020 Sep 03. - Publication Year :
- 2020
-
Abstract
- Porphyromonas gingivalis is a periodontal pathogen implicated in a range of pregnancy disorders that involve impaired spiral artery remodeling (ISAR) with or without fetal growth restriction (FGR). Using a rodent periodontitis model, we assessed the ability of P. gingivalis to produce ISAR and FGR in Sprague Dawley (SD) and Wistar (WIS) rats. Both infected SD and WIS rats developed ISAR, but only WIS rats developed FGR despite both rat strains having equivalent microbial loads within the placenta. Neither maternal systemic inflammation nor placental (fetal) inflammation was a feature of FGR in WIS rats. Unique to infected WIS rats, was loss of trophoblast cell density within the junctional zone of the placenta that was not present in SD tissues. In addition, infected WIS rats had a higher proportion of junctional zone trophoblast cells positive for cytoplasmic high temperature requirement A1 (Htra1), a marker of cellular oxidative stress. Our results show a novel phenomenon present in P. gingivalis-induced FGR, with relevance to human disease since dysregulation of placental Htra1 and placental oxidative stress are features of preeclamptic placentas and preeclampsia with FGR.
- Subjects :
- Animals
Arteries microbiology
Bacteroidaceae Infections microbiology
Female
Fetal Growth Retardation pathology
Male
Pregnancy
Rats
Rats, Sprague-Dawley
Rats, Wistar
Trophoblasts microbiology
Arteries pathology
Bacteroidaceae Infections complications
Fetal Growth Retardation etiology
Porphyromonas gingivalis pathogenicity
Trophoblasts pathology
Vascular Remodeling
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32884071
- Full Text :
- https://doi.org/10.1038/s41598-020-71762-9