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Co-occurrence of EBV-positive classic Hodgkin lymphoma and B-cell lymphomas of different clonal origins: A case report and literature review.
- Source :
-
Pathology international [Pathol Int] 2020 Nov; Vol. 70 (11), pp. 893-898. Date of Electronic Publication: 2020 Sep 03. - Publication Year :
- 2020
-
Abstract
- Although cases with metachronous or synchronous co-occurrence of classic Hodgkin lymphoma (CHL) and B-cell non-Hodgkin lymphoma (B-NHL) have been reported, few reports have analyzed the clonal relationship between both lesions in detail, especially in Epstein-Barr virus (EBV)-positive settings. Here, we report a case of a 38-year-old male with CHL, followed by the recurrence of EBV-positive mucocutaneous ulcers of the large intestine and EBV-positive diffuse large B-cell lymphoma in the liver. Surprisingly, polymerase chain reaction analysis for immunoglobulin heavy chain gene rearrangement revealed that all lesions were clonally distinct. We further reviewed the literature on synchronous and metachronous co-occurrence of CHL and B-NHL in EBV-positive settings. In contrast to EBV-negative settings, all evaluable cases showed clonally distinct multiple lesions. These findings suggest that histologically and clonally distinct B-cells could simultaneously proliferate in EBV-associated settings, providing a new insight into the pathogenesis of EBV-associated lymphoproliferative disorders.<br /> (© 2020 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Adult
Epstein-Barr Virus Infections diagnosis
Herpesvirus 4, Human metabolism
Hodgkin Disease diagnosis
Humans
Lymphoma, Large B-Cell, Diffuse diagnosis
Lymphoproliferative Disorders diagnosis
Lymphoproliferative Disorders pathology
Male
Neoplasm Recurrence, Local metabolism
Neoplasm Recurrence, Local pathology
Epstein-Barr Virus Infections pathology
Hodgkin Disease pathology
Lymphoma, Large B-Cell, Diffuse pathology
Lymphoproliferative Disorders virology
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1827
- Volume :
- 70
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Pathology international
- Publication Type :
- Academic Journal
- Accession number :
- 32881147
- Full Text :
- https://doi.org/10.1111/pin.13012