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First Total Synthesis of the Pavine Alkaloid (±)-Neocaryachine and Its Optical Resolution.
- Source :
-
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2020; Vol. 68 (9), pp. 899-902. - Publication Year :
- 2020
-
Abstract
- The first total synthesis of (±)-neocaryachine (1) was achieved using a radical cyclization to produce the dibenzo-9-azabicyclo[3.3.1]nonane pavine skeleton, following a Bischler-Napieralski reaction to construct an intermediate benzylisoquinoline. The resulting racemic mixture was separated by chiral column chromatography to provide pure (+)- and (-)-1.
Details
- Language :
- English
- ISSN :
- 1347-5223
- Volume :
- 68
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Chemical & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 32879231
- Full Text :
- https://doi.org/10.1248/cpb.c20-00370