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Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer: Review of the Literature and Perspectives of Clinical Research.
- Source :
-
Anticancer research [Anticancer Res] 2020 Sep; Vol. 40 (9), pp. 4819-4828. - Publication Year :
- 2020
-
Abstract
- Concurrent cisplatin-based chemotherapy and radiotherapy (CCRT) plus brachytherapy is standard treatment for locally advanced cervical cancer. Platinum-based neoadjuvant chemotherapy (NACT) followed by radical hysterectomy has been proposed as an alternative approach, especially for patients with stage Ib2-IIb disease. This review analyzes the most commonly used combination regimens in this clinical setting and the randomized trials comparing chemo-surgery versus definitive radiotherapy or CCRT. The combination of paclitaxel plus ifosfamide plus cisplatin (TIP regimen) obtained the highest rates of optimal pathological response, associated with elevated hematological toxicity. In a recent phase II study, a dose-dense regimen consisting of weekly paclitaxel plus carboplatin for 9 cycles has achieved optimal pathological response rates similar to those of TIP with better toxicity profile. Further studies are strongly warranted to better define the optimal regimen for the patients selected to receive NACT followed by radical surgery.<br /> (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols adverse effects
Chemoradiotherapy
Chemotherapy, Adjuvant
Female
Humans
Hysterectomy
Neoadjuvant Therapy
Prognosis
Treatment Outcome
Uterine Cervical Neoplasms pathology
Uterine Cervical Neoplasms radiotherapy
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Uterine Cervical Neoplasms drug therapy
Uterine Cervical Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 40
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 32878770
- Full Text :
- https://doi.org/10.21873/anticanres.14485