Back to Search
Start Over
Dietary Wheat Amylase Trypsin Inhibitors Impact Alzheimer's Disease Pathology in 5xFAD Model Mice.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 31; Vol. 21 (17). Date of Electronic Publication: 2020 Aug 31. - Publication Year :
- 2020
-
Abstract
- Wheat amylase trypsin inhibitors (ATIs) represent a common dietary protein component of gluten-containing cereals (wheat, rye, and barley). They act as toll-like receptor 4 ligands, and are largely resistant to intestinal proteases, eliciting a mild inflammatory response within the intestine after oral ingestion. Importantly, nutritional ATIs exacerbated inflammatory bowel disease and features of fatty liver disease and the metabolic syndrome in mice. For Alzheimer's disease (AD), both inflammation and altered insulin resistance are major contributing factors, impacting onset as well as progression of this devastating brain disorder in patients. In this study, we evaluated the impact of dietary ATIs on a well-known rodent model of AD (5xFAD). We assessed metabolic, behavioral, inflammatory, and microbial changes in mice consuming different dietary regimes with and without ATIs, consumed ad libitum for eight weeks. We demonstrate that ATIs, with or without a gluten matrix, had an impact on the metabolism and gut microbiota of 5xFAD mice, aggravating pathological hallmarks of AD. If these findings can be translated to patients, an ATI-depleted diet might offer an alternative therapeutic option for AD and warrants clinical intervention studies.
- Subjects :
- Alzheimer Disease etiology
Alzheimer Disease metabolism
Amylases chemistry
Animals
Diet adverse effects
Disease Models, Animal
Female
Immunity, Innate
Inflammation etiology
Inflammation metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Plaque, Amyloid metabolism
Trypsin chemistry
Alzheimer Disease pathology
Behavior, Animal
Gastrointestinal Microbiome
Inflammation pathology
Plaque, Amyloid pathology
Triticum enzymology
Trypsin Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 21
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32878020
- Full Text :
- https://doi.org/10.3390/ijms21176288