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Laser and anti-vascular endothelial growth factor treatment for drusenoid pigment epithelial detachment in age-related macular degeneration.
- Source :
-
Scientific reports [Sci Rep] 2020 Sep 01; Vol. 10 (1), pp. 14370. Date of Electronic Publication: 2020 Sep 01. - Publication Year :
- 2020
-
Abstract
- This study aims to report the 12 months results of efficacy and safety of laser photocoagulation and anti-vascular endothelial growth factor (VEGF) injections for drusenoid pigment epithelial detachment (dPED). In this prospective study, patients with treatment naïve bilateral intermediate age-related macular degeneration, featuring dPED, with visual acuity ≤ 83 letters were enrolled. The study group received PASCAL laser (532 nm) along the periphery of the dPED, and the fellow eye served as a control group. To prevent complications of choroidal neovascularization, intravitreal anti-VEGF injections to laser treated eye were performed on a 3-month interval up to 1 year. Primary outcomes-drusen area, PED height-and secondary outcomes-best-corrected visual acuity (BCVA), contrast sensitivity, degree of metamorphopsia, NEI-VFQ 25, and fundus autofluorescence-were analyzed. Among 21 patients, a total of 20 patients satisfied the 12 months follow-up. Drusen area and PED height decreased significantly in the laser group, while no significant change appeared in the control group (74.1% vs. - 3.5%, P < 0.001; 76.6% vs. 0.1%, P < 0.001). Mean BCVA improved 4.6 letters in the laser group (vs. 1.1 letters in the control group, P = 0.019). As for safety, one study eye developed retinal pigment epithelial tear, and one control eye developed retinal angiomatous proliferation. Low energy laser photocoagulation and anti-VEGF injection in eyes with dPED showed some improvement in visual acuity. dPED regressed without developing center involving GA in the study eye, but a longer term follow-up is necessary to reveal the efficacy and safety of these treatments. The 2-year results of this study will be followed to reveal long term efficacy and safety of the treatment for dPED.
- Subjects :
- Aged
Aged, 80 and over
Choroidal Neovascularization prevention & control
Female
Follow-Up Studies
Humans
Male
Middle Aged
Pilot Projects
Prospective Studies
Retinal Perforations etiology
Treatment Outcome
Visual Acuity
Angiogenesis Inhibitors administration & dosage
Bevacizumab administration & dosage
Geographic Atrophy complications
Low-Level Light Therapy adverse effects
Macular Degeneration drug therapy
Macular Degeneration radiotherapy
Retinal Detachment drug therapy
Retinal Detachment radiotherapy
Vascular Endothelial Growth Factor A antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32873842
- Full Text :
- https://doi.org/10.1038/s41598-020-71401-3