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Two novel antithetical KN blood group antigens may contribute to more than a quarter of all KN antisera in Europe.
- Source :
-
Transfusion [Transfusion] 2020 Oct; Vol. 60 (10), pp. 2408-2418. Date of Electronic Publication: 2020 Sep 01. - Publication Year :
- 2020
-
Abstract
- Background: All antigens described in the KN blood group system are located in the long homologous repeat D (LHR-D) of complement receptor 1 (CR1). While there have been reports that some sera react only with the long homologous repeat C (LHR-C), the antigens in LHR-C are unknown.<br />Study Design and Methods: Recombinant LHR-C and LHR-D were used to identify antibodies directed against LHR-C of CR1, into which a point mutation was introduced to characterize the underlying blood group antigens. In addition, database studies to define haplotypes of CR1 were performed.<br />Results: Several antisera were identified that were specific against CR1 p.1208His and against CR1 p.1208Arg, located in LHR-C. Fifteen KN haplotypes were found in the Ensembl genome browser. It was shown that due to a linkage disequilibrium anti-CR1 p.1208His may be mistaken for anti-KCAM.<br />Conclusion: A novel antithetical KN blood group antigen pair was found at position p.1208 of CR1, for which the names DACY and YCAD are proposed. Antibodies against these two novel antigens seem to contribute to more than a quarter of all KN sera in Europe.<br /> (© 2020 AABB.)
- Subjects :
- Amino Acid Substitution
Antibodies chemistry
Antibodies immunology
Europe
Humans
Protein Domains
Recombinant Proteins chemistry
Recombinant Proteins genetics
Recombinant Proteins immunology
Blood Group Antigens chemistry
Blood Group Antigens genetics
Blood Group Antigens immunology
Point Mutation
Polymorphism, Genetic
Receptors, Complement 3b chemistry
Receptors, Complement 3b genetics
Receptors, Complement 3b immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-2995
- Volume :
- 60
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Transfusion
- Publication Type :
- Academic Journal
- Accession number :
- 32870515
- Full Text :
- https://doi.org/10.1111/trf.16039