Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus.

Authors :: Galindo-Hernandez O
Machado-Contreras JR
Martinez-Corella R
Romero-Garcia T
Vazquez-Jimenez JG
Source :: Archives of medical science : AMS [Arch Med Sci] 2020 Aug 10; Vol. 16 (5), pp. 1226-1228. Date of Electronic Publication: 2020 Aug 10 (Print Publication: 2020).
Publication Year :: 2020
Abstract: We examined the association between sarco/endoplasmic reticulum calcium ATPase (SERCA) expression and glycated hemoglobin (HbA <subscript>1c</subscript> ) levels since alterations in this protein expression are associated with the genesis of insulin resistance. HbA1c levels and SERCA protein expression from platelets of Mexican patients diagnosed with type 2 diabetes mellitus (T2DM) were analyzed showing lower values of SERCA expression against the normal values we find in healthy people. Interestingly, as diabetes condition got worse; SERCA protein expression decreased gradually until it was undetectable. The results showed an inverse correlation between HbA <subscript>1c</subscript> and SERCA protein expression in T2DM patients. .<br />Competing Interests: The authors declare no conflict of interest.<br /> (Copyright: © 2020 Termedia & Banach.)

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