Back to Search
Start Over
SLC Neurotransmitter Transporters as Therapeutic Targets for Alcohol Use Disorder: A Narrative Review.
- Source :
-
Alcoholism, clinical and experimental research [Alcohol Clin Exp Res] 2020 Oct; Vol. 44 (10), pp. 1965-1976. Date of Electronic Publication: 2020 Sep 20. - Publication Year :
- 2020
-
Abstract
- Alcohol use disorder (AUD) is 1 of the most prevalent of all substance use disorders and contributes significantly to global disease burden. Despite its prevalence, <10% of individuals with AUD receive treatment. A significant barrier to receiving treatment is a lack of effective pharmacotherapies. While 3 medications have been approved by the FDA for AUD (disulfiram, acamprosate, naltrexone), their efficacy remains low. Furthermore, a number of undesirable side effects associated with these drugs further reduce patient compliance. Thus, research into new effective pharmacotherapies for AUD is warranted. Due to their involvement in regulating synaptic neurotransmitter levels, solute carrier (SLC) transporters could be targeted for developing effective treatment strategies for AUD. Indeed, a number of studies have shown beneficial reductions in alcohol consumption through the use of drugs that target transporters of dopamine, serotonin, glutamate, glycine, and GABA. The purpose of this narrative review is to summarize preclinical and clinical studies from the last 2 decades targeting SLC neurotransmitter transporters for the treatment of AUD. Limitations, as well as future directions for expanding this field, are also discussed.<br /> (© 2020 by the Research Society on Alcoholism.)
- Subjects :
- Amino Acid Transport System X-AG metabolism
Amino Acid Transport System X-AG physiology
Animals
Dopamine metabolism
Dopamine physiology
GABA Plasma Membrane Transport Proteins metabolism
GABA Plasma Membrane Transport Proteins physiology
Glycine Plasma Membrane Transport Proteins drug effects
Glycine Plasma Membrane Transport Proteins metabolism
Glycine Plasma Membrane Transport Proteins physiology
Humans
Neurotransmitter Agents physiology
Serotonin metabolism
Serotonin physiology
Solute Carrier Proteins metabolism
Solute Carrier Proteins physiology
Alcoholism drug therapy
Neurotransmitter Agents metabolism
Solute Carrier Proteins drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1530-0277
- Volume :
- 44
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Alcoholism, clinical and experimental research
- Publication Type :
- Academic Journal
- Accession number :
- 32862443
- Full Text :
- https://doi.org/10.1111/acer.14445