Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin-mediated mitophagy.

Subjects

Subjects :

Adenosine Triphosphate metabolism
Alzheimer Disease etiology
Amyloid beta-Peptides metabolism
Brain-Derived Neurotrophic Factor metabolism
Disease Progression
Humans
Mitochondria physiology
Mitochondrial Diseases complications
NAD physiology
Niacinamide analogs & derivatives
Niacinamide physiology
Nicotinamide Mononucleotide physiology
Pyridinium Compounds
Reactive Oxygen Species metabolism
Alzheimer Disease prevention & control
Exercise physiology
Forkhead Box Protein O1 physiology
Mitochondrial Diseases therapy
Mitophagy physiology
Protein Kinases physiology
Sirtuin 1 physiology
Ubiquitin-Protein Ligases physiology

Details

Language :

English

ISSN :

2213-2961

Volume :

10

Issue :

1

Database :

MEDLINE

Journal :

Journal of sport and health science

Publication Type :

Academic Journal

Accession number :

32861777

Full Text :

https://doi.org/10.1016/j.jshs.2020.08.009