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Impaired catecholamine secretion as a cause of diabetic autonomic neuropathy.
- Source :
-
Diabetes research and clinical practice [Diabetes Res Clin Pract] 1988 Apr 06; Vol. 4 (4), pp. 303-7. - Publication Year :
- 1988
-
Abstract
- Human and animal studies were performed to investigate the causes of diabetic autonomic neuropathy. Human diabetics, with and without autonomic neuropathy, were measured for plasma catecholamine response to insulin hypoglycemia and for urinary catecholamine excretion. In streptozotocin-diabetic rats, plasma catecholamine response and tissue catecholamine concentrations were measured at various stages of the disease. As the duration of the diabetic state lengthens in rats, there is a time-proportional stepwise decrease in plasma catecholamine response. This is similar to the clinical course observed in human diabetics, which also includes a reduction of catecholamine excretion after the appearance of autonomic neuropathy. After 6 weeks of diabetes, rat tissue is found to have an increased concentration of catecholamines; this may represent a compensatory reaction to the difficulties of secretion. At 13 weeks of diabetes, tissue catecholamine concentrations return to almost normal, when plasma responses have disappeared. These results suggest that the impaired secretion of catecholamines in diabetics may be a cause of diabetic autonomic neuropathy.
- Subjects :
- Animals
Autonomic Nervous System Diseases physiopathology
Catecholamines metabolism
Diabetes Mellitus, Experimental physiopathology
Diabetic Neuropathies physiopathology
Humans
Hypotension, Orthostatic
Insulin therapeutic use
Norepinephrine blood
Rats
Autonomic Nervous System Diseases etiology
Diabetic Neuropathies etiology
Epinephrine urine
Norepinephrine urine
Subjects
Details
- Language :
- English
- ISSN :
- 0168-8227
- Volume :
- 4
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Diabetes research and clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 3286167
- Full Text :
- https://doi.org/10.1016/s0168-8227(88)80033-0