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A Robust Au-C≡C Functionalized Surface: Toward Real-Time Mapping and Accurate Quantification of Fe 2+ in the Brains of Live AD Mouse Models.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Nov 09; Vol. 59 (46), pp. 20499-20507. Date of Electronic Publication: 2020 Oct 12. - Publication Year :
- 2020
-
Abstract
- Described here is that Au-C≡C bonds showed the highest stability under biological conditions, with abundant thiols, and the best electrochemical performance compared to Au-S and Au-Se bonds. The new finding was also confirmed by theorical calculations. Based on this finding, a specific molecule for recognition of Fe <superscript>2+</superscript> was designed and synthesized, and used to create a selective and accurate electrochemical sensor for the quantification of Fe <superscript>2+</superscript> . The present ratiometric strategy demonstrates high spatial resolution for real-time tracking of Fe <superscript>2+</superscript> in a dynamic range of 0.2-120 μM. Finally, a microelectrode array with good biocompatibility was applied in imaging and biosensing of Fe <superscript>2+</superscript> in the different regions of live mouse brains. Using this tool, it was discovered that the uptake of extracellular Fe <superscript>2+</superscript> into the cortex and striatum was largely mediated by cyclic adenosine monophosphate (cAMP) through the CREB-related pathway in the brain of a mouse with Alzheimer's disease.<br /> (© 2020 Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 59
- Issue :
- 46
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 32857422
- Full Text :
- https://doi.org/10.1002/anie.202006318