Back to Search
Start Over
Antinociceptive efficacy and safety of subcutaneous buprenorphine hydrochloride administration in African pygmy hedgehogs ( Atelerix albiventris ).
- Source :
-
Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2020 Sep 15; Vol. 257 (6), pp. 618-623. - Publication Year :
- 2020
-
Abstract
- Objective: To evaluate antinociceptive efficacy and safety of SC buprenorphine hydrochloride administration in African pygmy hedgehogs ( Atelerix albiventris ).<br />Animals: 12 healthy adult hedgehogs (7 males and 5 females).<br />Procedures: 3 crossover experimental trials were performed. In the first trial, all 12 hedgehogs were given single SC injections of buprenorphine (0.01 mg/kg [0.0045 mg/lb]), buprenorphine (0.03 mg/kg [0.014 mg/lb]), or saline (0.9% NaCl) solution (0.16 mL/kg [0.073 mL/lb]), and sedation and hind limb thermal withdrawal latency were measured. In the second trial, 6 hedgehogs were given single SC injections of buprenorphine (0.05 mg/kg [0.023 mg/lb]) or saline solution (0.16 mL/kg), and sedation and withdrawal latency were evaluated. In the third trial, 10 hedgehogs were given 3 doses of buprenorphine (0.05 mg/kg, SC, q 24 h) or saline solution (0.16 mL/kg, SC, q 24 h), and food intake and body weight were measured for 6 days.<br />Results: For all 3 experimental trials, the sedation score was 0 for all hedgehogs at all assessment times. A single 0.01-mg/kg dose of buprenorphine significantly increased thermal withdrawal latency for 36 hours, and single 0.03- and 0.05-mg/kg doses significantly increased latencies for 48 hours. Increased locomotor activity was noted in a few hedgehogs after administration of the 0.03- and 0.05-mg/kg doses. Daily administration of buprenorphine did not have significant effects on food intake or body weight.<br />Conclusions and Clinical Relevance: SC administration of buprenorphine at single doses of 0.01, 0.03, and 0.05 mg/kg provided safe, long-lasting antinociception in African pygmy hedgehogs without apparent sedative effects.
- Subjects :
- Analgesics
Animals
Cross-Over Studies
Female
Hedgehogs
Male
Buprenorphine
Subjects
Details
- Language :
- English
- ISSN :
- 1943-569X
- Volume :
- 257
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of the American Veterinary Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 32857008
- Full Text :
- https://doi.org/10.2460/javma.257.6.618