Back to Search
Start Over
COLIA1 + 1245 G > T Sp1 Binding Site Polymorphism is Not Associated with ACL Injury Risks Among Indian Athletes.
- Source :
-
Indian journal of orthopaedics [Indian J Orthop] 2020 Apr 28; Vol. 54 (5), pp. 647-654. Date of Electronic Publication: 2020 Apr 28 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Objective: Type I collagen polypeptides contribute significantly to the structural composition of ligament tissue matrix. Since anterior cruciate ligament (ACL) tears account for roughly 50% of all knee injuries in sports, the objective of the study was to investigate association of Sp1-transcription factor binding site polymorphism COLIA1 Sp1 + 1245 G > T with ACL injury risk among Indian athletes.<br />Methods: A total of 166 athletes (90 with ACL tears and 76 as control) were recruited and were genotyped for COLIA1 Sp1 + 1245 G > T polymorphism using allele-specific PCR (AS-PCR) method.<br />Result: Both the groups were matched for nature of sports, training regimen, and other demographic characteristics. We observed no significant difference between ACL cases and control group in GT or TT genotype frequency distribution ( p = 0.967) and T-allele frequency distribution ( p = 0.861) for COLIA1 Sp1 + 1245 G > T polymorphism. Also, the three models of inheritance of minor allele failed to show any statistical significance in the present study.<br />Conclusion: COLIA1 Sp1 + 1245 G > T polymorphism has been studied in relation to many connective tissue pathologies. This is probably the first study to investigate the association of collagen protein genes with ACL injury risk on Indian athletes. Further studies with more SNPs in genes encoding fibril-forming collagen and large sample sizes are necessary to fully understand the genetic link to ACL injuries among athletes.<br />Competing Interests: Conflict of interestManish shukla, Rahul Gupta, Vivek Pandey, Pramod Kumar Tiwari and Rabbind Singh Amrathlal declare that they have no competing interests.<br /> (© Indian Orthopaedics Association 2020.)
Details
- Language :
- English
- ISSN :
- 0019-5413
- Volume :
- 54
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Indian journal of orthopaedics
- Publication Type :
- Academic Journal
- Accession number :
- 32850029
- Full Text :
- https://doi.org/10.1007/s43465-020-00119-1