Back to Search
Start Over
Pharmacokinetics of high-dose etoposide.
- Source :
-
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 1988 May; Vol. 43 (5), pp. 561-4. - Publication Year :
- 1988
-
Abstract
- The pharmacokinetics of etoposide at doses of 1 gm/m2 to 3 gm/m2 were studied in patients with hematologic malignancies. The noncompartmental systemic clearance, mean residence time, steady-state volume of distribution, and elimination half-life were independent of the dose of etoposide, whereas the AUC was proportional to the dose. Comparison of these results with those reported previously indicates that etoposide exhibits linear pharmacokinetics over a thirtyfold range in doses (0.1 to 3 gm/m2).
Details
- Language :
- English
- ISSN :
- 0009-9236
- Volume :
- 43
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 3284691
- Full Text :
- https://doi.org/10.1038/clpt.1988.73