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Retinol palmitate against toxicogenic damages of antineoplastic drugs on normal and tumor cells.
- Source :
-
Chemico-biological interactions [Chem Biol Interact] 2020 Oct 01; Vol. 330, pp. 109219. Date of Electronic Publication: 2020 Aug 23. - Publication Year :
- 2020
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Abstract
- The lack of tissue selectivity of anticancer drugs generates intense collateral and adverse effects of cancer patients, making the incorporation of vitamins or micronutrients into the diet of individuals to reduce side or adverse effects of antineoplastics. The study aimed to evaluate the effects of retinol palmitate (RP) on the toxicogenic damages induced by cyclophosphamide (CPA), doxorubicin (DOX) and its association with the AC protocol (CPA + DOX), in Sarcoma 180 (S-180) tumor cell line, using the micronuclei test with a block of cytokinesis (CBMN); and in non-tumor cells derived from Mus musculus using the comet assay. The results suggest that CPA, DOX and AC protocol induced significant toxicogenic damages (P < 0.05) on the S-180 cells by induction of micronuclei, cytoplasmic bridges, nuclear buds, apoptosis, and cell necrosis, proving their antitumor effects, and significant damage (P < 0.001) to the genetic material of peripheral blood cells of healthy mice, proving the genotoxic potential of these drugs. However, RP modulated the toxicogenic effects of antineoplastic tested both in the CBMN test (P < 0.05), at the concentrations of 1, 10 and 100 IU/mL; as in the comet assay (P < 0.001) at the concentration of 100 IU/kg for the index and frequency of genotoxic damage. The accumulated results suggest that RP reduced the action of antineoplastics in non-tumor cells as well as the cytotoxic, mutagenic, and cell death in neoplastic cells.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Combined Chemotherapy Protocols adverse effects
Antineoplastic Combined Chemotherapy Protocols toxicity
Apoptosis drug effects
Cell Line
Cell Line, Tumor
Comet Assay
Cyclophosphamide adverse effects
Cyclophosphamide toxicity
DNA Damage drug effects
Dose-Response Relationship, Drug
Doxorubicin adverse effects
Doxorubicin toxicity
Drug Interactions
Humans
Mice
Micronucleus Tests
Mutagenesis drug effects
Retinyl Esters
Vitamin A pharmacology
Antineoplastic Agents toxicity
Diterpenes pharmacology
Vitamin A analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7786
- Volume :
- 330
- Database :
- MEDLINE
- Journal :
- Chemico-biological interactions
- Publication Type :
- Academic Journal
- Accession number :
- 32846153
- Full Text :
- https://doi.org/10.1016/j.cbi.2020.109219