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Association between 25(OH) vitamin D and graft survival in renal transplanted children.
- Source :
-
Pediatric transplantation [Pediatr Transplant] 2020 Nov; Vol. 24 (7), pp. e13809. Date of Electronic Publication: 2020 Aug 26. - Publication Year :
- 2020
-
Abstract
- Background: In children, vitamin D deficiency is common after renal transplantation. Besides promoting bone and muscle development, vitamin D has immunomodulatory effects, which could protect kidney allografts. The purpose of this study was to assess the association between vitamin D status and the occurrence of renal rejection.<br />Methods: We studied a retrospective cohort of 123 children, who were transplanted at a single institution between September 2008 and April 2019. Patients did not receive vitamin D supplementation systematically. In addition, factors influencing vitamin D status were analyzed using univariate and multivariate analyses.<br />Results: Median 25-hydroxy-vitamin D (25-OH-D) concentration was close to reference values at the time of transplantation (30 ng/mL (min-max 5-100)), but rapidly decreased within the first 3 months to 19 ng/mL (min-max 3-91) (P < .001). The overall acute rejection rate was 7%. The clinical rejection rate (5% vs 9%), subclinical rejection (12% vs 36%), and borderline changes (21% vs 28%) were not statistically different during the follow-up between the 3-month 25-OH-D < 20 ng/mL and 3-month 25-OH-D > 20 ng/mL groups. There was a correlation between the 25-OH-D levels and PTH concentration at 3 months (r = -.2491, P = .01), but no correlation between the 3-month 25-OH-D and the season of the year (F = 0.19, P = .90; F = 1.34, P = .27, respectively). Multivariate analyses revealed that age and mGFR at 3 months, were independent predictors of mGFR at 12 months.<br />Conclusion: Our data show that vitamin D deficiency can develop rapidly after transplantation; vitamin D levels at 3 months are not associated with lower mGFR or a higher rejection rate at 1 year in children as opposed to adult recipients.<br /> (© 2020 Wiley Periodicals LLC.)
- Subjects :
- Adolescent
Allografts
Biomarkers blood
Child
Child, Preschool
Female
Follow-Up Studies
France epidemiology
Graft Rejection blood
Graft Rejection epidemiology
Graft Survival
Humans
Incidence
Infant
Infant, Newborn
Male
Radioimmunoassay
Retrospective Studies
Seasons
Survival Rate trends
Transplant Recipients
Vitamin D blood
Vitamin D Deficiency blood
Vitamin D Deficiency epidemiology
Graft Rejection etiology
Kidney Transplantation adverse effects
Vitamin D analogs & derivatives
Vitamin D Deficiency complications
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3046
- Volume :
- 24
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Pediatric transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 32845557
- Full Text :
- https://doi.org/10.1111/petr.13809