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Bone-Specific Drug Delivery for Osteoporosis and Rare Skeletal Disorders.
- Source :
-
Current osteoporosis reports [Curr Osteoporos Rep] 2020 Oct; Vol. 18 (5), pp. 515-525. - Publication Year :
- 2020
-
Abstract
- Purpose of Review: The skeletal system provides an important role to support body structure and protect organs. The complexity of its architecture and components makes it challenging to deliver the right amount of the drug into bone regions, particularly avascular cartilage lesions. In this review, we describe the recent advance of bone-targeting methods using bisphosphonates, polymeric oligopeptides, and nanoparticles on osteoporosis and rare skeletal diseases.<br />Recent Findings: Hydroxyapatite (HA), a calcium phosphate with the formula Ca <subscript>10</subscript> (PO <subscript>4</subscript> ) <subscript>6</subscript> (OH) <subscript>2</subscript> , is a primary matrix of bone mineral that includes a high concentration of positively charged calcium ion and is found only in the bone. This unique feature makes HA a general targeting moiety to the entire skeletal system. We have applied bone-targeting strategy using acidic amino acid oligopeptides into lysosomal enzymes, demonstrating the effects of bone-targeting enzyme replacement therapy and gene therapy on bone and cartilage lesions in inherited skeletal disorders. Virus or no-virus gene therapy using techniques of engineered capsid or nanomedicine has been studied preclinically for skeletal diseases. Efficient drug delivery into bone lesions remains an unmet challenge in clinical practice. Bone-targeting therapies based on gene transfer can be potential as new candidates for skeletal diseases.
- Subjects :
- Alkaline Phosphatase administration & dosage
Amino Acids, Acidic
Bone Density Conservation Agents administration & dosage
Calcitonin administration & dosage
Chondroitinsulfatases administration & dosage
Diphosphonates
Drug Delivery Systems
Durapatite
Enzyme Replacement Therapy
Humans
Nanoparticles
Oligopeptides
Parathyroid Hormone administration & dosage
Bone Diseases drug therapy
Hypophosphatasia drug therapy
Mucopolysaccharidosis IV drug therapy
Osteoporosis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1544-2241
- Volume :
- 18
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Current osteoporosis reports
- Publication Type :
- Academic Journal
- Accession number :
- 32845464
- Full Text :
- https://doi.org/10.1007/s11914-020-00620-4