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Microwave-Induced Ugi-Four Component Reactions: Synthesis of New Hetero- Steroid-Amino Acid Conjugates.
- Source :
-
Current organic synthesis [Curr Org Synth] 2020; Vol. 17 (8), pp. 641-647. - Publication Year :
- 2020
-
Abstract
- Background: Aza-steroids are an important class of compounds because of their numerous biological activities. The hetero steroids have different hydrogen bonding ability and hydrophobicity in comparison to steroids.<br />Materials and Methods: Microwave-induced synthesis of a novel type of hybrid hetero-steroid amine conjugates, following Ugi-four component reactions of steroidal amines with alanine and valine methyl esters as amino acid residues is described. Specifically, hetero-steroid-amino acid conjugate based on D-ring fused hetero steroidal amine, hetero-steroid-amino acid conjugate based on A-ring hetero steroidal amine, and hetero-steroidamino acid conjugate based on B-ring hetero steroidal amine are synthesized.<br />Results and Discussion: The yield of the products under microwave-induced process was considerably higher than that obtained by the conventional method. In contrast to the conventional method for the synthesis of these molecules, microwave-induced method has several advantages.<br />Conclusion: These include rapid reaction, a superior yield of the product, minimum side reaction, and economical microwave-induced process.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Details
- Language :
- English
- ISSN :
- 1570-1794
- Volume :
- 17
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Current organic synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 32842943
- Full Text :
- https://doi.org/10.2174/1570179417666200825164654