Back to Search
Start Over
Prevalence of asymptomatic deep vein thrombosis in patients hospitalized with SARS-CoV-2 pneumonia: a cross-sectional study.
- Source :
-
Internal and emergency medicine [Intern Emerg Med] 2020 Nov; Vol. 15 (8), pp. 1425-1433. Date of Electronic Publication: 2020 Aug 25. - Publication Year :
- 2020
-
Abstract
- The association between coronavirus disease 2019 (COVID-19) pneumonia and venous thrombotic disorders is still unclear. We assessed the association between COVID-19 infection-related pneumonia and proximal deep-vein thrombosis (DVT) in a cohort of patients admitted to our hospital during the European outbreak in the front line of Cremona, Lombardy. In a single-center cross-sectional study, all patients hospitalized for more than 5 days in Internal Medicine Department with confirmed COVID-19 pneumonia received 2-point compressive ultrasound assessment (CUS) of the leg vein system during a single day. Ninety-four percent of patients received enoxaparin as standard pharmacological prophylaxis for venous thromboembolism. The presence of DVT was defined as incompressibility of popliteal or common femoral vein. Out of 121 patients with COVID-19 pneumonia (mean age 71.8, 66.3% males) hospitalized on March 31st, 70 stayed in hospital for over 5 days and 66 of them underwent CUS of deep venous system of the legs. The presence of asymptomatic DVT was found in 9 patients (13.6%). No symptomatic DVT was found. Patients with DVT showed mean age = 75.7 years, mean D-dimer levels = 4.02 ng/ml and all of them received enoxaparin for thromboprophylaxis, except one. Computed tomography pulmonary angiogram confirmed pulmonary embolism in five patients. One every seven patients with COVID-19-related pneumonia, hospitalized for more than 5 days, had asymptomatic proximal DVT and half of them had confirmed PE despite standard pharmacological thromboprophylaxis. This observational study suggests the need of an active surveillance through CUS in patients hospitalized with acute SARS-COV-2 and underline the need of a more intense thromboprophylaxis.
- Subjects :
- Aged
Aged, 80 and over
Asymptomatic Diseases epidemiology
COVID-19
Coronavirus Infections epidemiology
Cross-Sectional Studies
Female
Humans
Italy epidemiology
Male
Middle Aged
Pandemics
Pneumonia epidemiology
Pneumonia, Viral epidemiology
Prevalence
Tomography, X-Ray Computed methods
Ultrasonography methods
Venous Thrombosis epidemiology
Venous Thrombosis physiopathology
Coronavirus Infections complications
Pneumonia etiology
Pneumonia, Viral complications
Venous Thrombosis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1970-9366
- Volume :
- 15
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Internal and emergency medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32840805
- Full Text :
- https://doi.org/10.1007/s11739-020-02472-3